Coverart for item
The Resource The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, PhD

The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, PhD

Label
The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level
Title
The Philadelphia chromosome
Title remainder
a mutant gene and the quest to cure cancer at the genetic level
Statement of responsibility
Jessica Wapner ; foreword by Robert A. Weinberg, PhD
Creator
Subject
Genre
Language
eng
Summary
This work discusses the history of a genetic mutation, discovered in 1959, that causes chronic myeloid leukemia, and traces the research and breakthroughs that led to the creation of a drug that makes this once-fatal illness now treatable. It focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent development of "Gleevec," is the keynote of this publication
Summary
Discusses the history of a genetic mutation, discovered in 1959, that causes chronic myeloid leukemia, and traces the research and breakthroughs that led to the creation of a drug that makes this once-fatal illness now treatable
Tone
Writing style
http://library.link/vocab/ext/novelist/bookUI
10179022
Cataloging source
DNLM/DLC
http://library.link/vocab/creatorName
Wapner, Jessica
Dewey number
616.99/419042
Illustrations
illustrations
Index
index present
LC call number
RC643
LC item number
.W36 2013
Literary form
non fiction
Nature of contents
bibliography
http://library.link/vocab/resourcePreferred
True
http://library.link/vocab/subjectName
  • Hungerford, David S
  • Chronic myeloid leukemia
  • Chronic myeloid leukemia
  • Cancer
  • Cancer
  • Mutation (Biology)
  • Imatinib
  • Philadelphia Chromosome
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • United States
  • Genetic Therapy
  • Fusion Proteins, bcr-abl
Target audience
adult
http://bibfra.me/vocab/lite/titleRemainder
a mutant gene and the quest to cure cancer at the genetic level
Label
The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, PhD
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Down to the bone : February 2012 -- The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes" -- Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man" -- Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory -- A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer -- Survival time
Control code
ocn820450840
Dimensions
24 cm
Extent
xiii, 303 pages
Isbn
9781615190676
Lccn
2012047686
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
illustrations
System control number
(OCoLC)820450840
Label
The Philadelphia chromosome : a mutant gene and the quest to cure cancer at the genetic level, Jessica Wapner ; foreword by Robert A. Weinberg, PhD
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
Down to the bone : February 2012 -- The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes" -- Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man" -- Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory -- A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer -- Survival time
Control code
ocn820450840
Dimensions
24 cm
Extent
xiii, 303 pages
Isbn
9781615190676
Lccn
2012047686
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
illustrations
System control number
(OCoLC)820450840

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